ovarian cancer cell — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
TN1839	Kumatakenin	Jaranol,Kaempferol 3,7-O-dimethyl ether	Apoptosis , Anti-infection
	Kumatakenin can suppress >80% of the SOS-inducing activity of Trp-P-1 at <0.06 micromol/mL.		Apoptosis , Anti-infection
T24557	NSC756093	NSC-756093,NSC 756093	Others
	NSC756093 potentially inhibits GBP1:PIM1 interaction. NSC756093 can be used in ovarian cancer studies.		Others
T6207	SC144		Apoptosis , Interleukin
	SC144 is an orally active small-molecule gp130 inhibitor.		Apoptosis , Interleukin
T2679	BMS-265246	BMS265246	CDK
	BMS-265246 is a potent and selective CDK1/2 inhibitor.		CDK
T2617	SNS-314 Mesylate	SNS-314	Aurora Kinase
	SNS-314 Mesylate (SNS-314) is an effective and specific Aurora A/B/C inhibitor (IC50: 9/31/3 nM). It is less inhibition of Trk A/B, Fms, Flt4, c-Raf, Axl, and DDR2.		Aurora Kinase
T34262	RAPTA-C		Apoptosis
	RAPTA-C induces EAC cell cycle arrest and apoptosis via the mitochondrial and p53-JNK pathways, and can be used in the study of breast and ovarian cancer.		Apoptosis
T12238	NNC 55-0396	NNC 55-0396 dihydrochloride	Calcium Channel
	NNC 55-0396 is a highly selective blocker of T-type calcium channel with IC50 of 6.8 μM. NNC 55-0396 can be used in studies about preventing human ovarian cancer cell proliferation.		Calcium Channel
T16680	PTC-028		Apoptosis , BMI-1
	PTC-028 selectively suppresses cancer cells whereas normal cells remain unaffected. PTC-028 is an orally bioavailable inhibitor of stem cell factor BMI-1 in ovarian cancer. The depletion of BMI-1 by PTC-028 causes caspas...		Apoptosis , BMI-1
T67741	SU056		Others
	SU056 is a YB-1 inhibitor. SU056 interacts with YB-1 and inhibits and downstream proteins and pathways. SU056 can induce cell-cycle arrest, apoptosis, and inhibit cell migration in ovarian cancer cells.		Others
T5780	HYPOCRELLIN B		Apoptosis , Parasite , Antifungal
	HYPOCRELLIN B are photosensitive pigments isolated from Hypocrella bambusae Sacc. Hypocrellin B causes DNA strand breakage, induces apoptosis in ovarian cancer cells, and inhibits proliferation of Staphylococcus by incre...		Apoptosis , Parasite , Antifungal
T60039	KSQ-4279	USP1-IN-1	PARP , DUB
	KSQ-4279 (USP1-IN-1) is an inhibitor of USP1 and PARP.KSQ-4279 has anticancer activity and is used in the study of non-small cell lung cancer, osteosarcoma, ovarian, breast, glioblastoma, bladder, uterine and pancreatic ...		PARP , DUB
T21883	Gedunin		HSP
	Gedunin is an important limonoid present in several genera of the Meliaceae family, mainly in seeds. Gedunin is an Hsp90 inhibitor, and inhibits ovarian cancer cell proliferation.		HSP
T3923	Calycosin	Cyclosin,3'-Hydroxyformononetin	Apoptosis , Tyrosinase
	Calycosin (Cyclosin) acts as a selective estrogen receptor modulator. Calycosin induces apoptosis in human ovarian cancer SKOV3 cells by activating caspases and Bcl-2 family proteins. Calycosin suppresses breast cancer c...		Apoptosis , Tyrosinase
T8464	RA-9		Apoptosis , DUB
	RA-9 is a potent and selective proteasome-associated inhibitor of deubiquitinating enzymes (DUBs), with favorable toxicity profile and anticancer activity. RA-9 selectively induces apoptosis in ovarian cancer cell lines.		Apoptosis , DUB
T35749	Thymohydroquinone	Thymoquinol	Antioxidant , Reactive Oxygen Species
	Thymohydroquinone (Thymoquinol) is a monoterpenoid phenolic compound found in thyme, oregano, and other plants in the labiaceae family. Thymohydroquinone inhibits cancer cell growth, reduces oxidative stress and modulate...		Antioxidant , Reactive Oxygen Species
T17155	Trabectedin	Ecteinascidin 743,ET-743	Apoptosis , Reactive Oxygen Species
	Trabectedin (Ecteinascidin 743) has potent antitumor activity and the potential for soft tissue sarcoma and ovarian cancer research. Trabectedin inhibits cell growth of MX-1, MCF7 and MCF7/DXR cells with IC50 values of 0...		Apoptosis , Reactive Oxygen Species
T16328	Nitroaspirin	NCX 4016	Apoptosis , COX
	Nitroaspirin (NCX 4016) is a nitric oxide donor and a nitro-derivative of Aspirin, which combines with Nitroaspirin to inhibit cyclooxygenase. Nitroaspirin induces significant induction of cell cycle arrest and apoptosis...		Apoptosis , COX
T36674	DMU-212		Apoptosis , ERK
	DMU-212 is a methylated derivative of Resveratrol , with antimitotic, anti-proliferative, antioxidant and apoptosis promoting activities. DMU-212 induces mitotic arrest via induction of apoptosis and activation of ERK1/2...		Apoptosis , ERK
T24879	Thioxodihydroquinazolinone-19	Thioxodihydroquinazolinone19
	In platinum-resistant A2780cis human ovarian cancer cells, thioxodihydroquinazolinone-19 is an inducer of apoptotic cell death. It acts by exhibiting a strong inhibitory effect in ovarian CSC-LCs in combination with cisp...
T71998	673-A
	673-A is an aldehyde dehydrogenase (ALDH1A) inhibitor that depletes CD133+ cancer stem cells (CSC) in ovarian cancer cell lines. 673-A triggers necroptosis in ovarian CSCs and induces expression of mitochondrial uncoupli...